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Regioselective Alkylation of 1,4,5-Trihydroxy-9,10-anthraquinone with Formaldehyde and Glyoxylic Acid

✍ Scribed by Dr. Karsten Krohn


Book ID
101551271
Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
220 KB
Volume
18
Category
Article
ISSN
0044-8249

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Reactions of 4-Oxoalkanoic Acids, 4. Syn
✍ Wedler, Christine ;Schick, Hans ;Scharfenberg-Pfeiffer, Doris ;Reck, GΓΌnter πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 432 KB

## Abstract Ethyl 4‐oxoalkanoates 1 react at ambient temperature in dry methanol in the presence of molecular sieve 3 Γ… in almost quantitative yield with 3‐aminopropanol and 2‐aminoethanol to form the bicyclic lactams __rac__‐2 and __rac__‐3, respectively. Surprisingly, the (Β±)‐5‐alkyl‐4‐oxa‐1‐azab