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Regioselective additions of grignard and lithium reagents to 2-[(benzylidene)aminoi]benzonitrile and 2-[(diphenylmethylene)amino]benzonitrile

✍ Scribed by L. Strekowski; M.T. Cegla; D.B. Harden; J.L. Mokrosz; M.J. Mokrosz

Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 301 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)80470-0

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✦ Synopsis

Phenyhnagnesium bromide and methyhnagnesium bromide in tetmhydrofuran undergo a regiose lective addition to the cyan0 group of the two title compounds. Phenyllithium and methyllithhnn add selectively to the azomethine portion of 2-[(benzylidene)anko]benzonitrile, but to the cyano group of Z[(diphenylmethylene)amino]benzonitrile. These addition reactions are utilized in the synthesis of quinazoline derivatives.

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