Regioselective acylation at the 5- or 6-position of l-tryptophan derivatives
✍ Scribed by Yongwen Jiang; Dawei Ma
- Book ID
- 104251890
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 61 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The reaction of 1-acyl tryptophan derivatives with chloroacetyl chloride or the reaction of 1-tosyl tryptophan derivatives with acetyl chloride provides the corresponding 6-acylation products, while acylation of the 3-oxo tryptophan derivative gives a 5-substituted product.
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## Abstract The enzymatic synthesis of l‐tryptophan and its derivative 5′‐hydroxy‐l‐tryptophan labeled with deuterium and tritium at the α‐carbon position is reported. The mixture containing __S__‐methyl‐l‐cysteine, indole or 5‐hydroxyindole dissolved in deuteriated or tritiated water has been conv