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Regioselective Activation of Aminothiazole(iminoxyacetic acid)acetic Acid: An Efficient Synthesis of the Monobactam Aztreonam

โœ Scribed by Singh, Janak; Denzel, Theodor W.; Fox, Rita; Kissick, Thomas P.; Herter, Rolf; Wurdinger, Joseph; Schierling, Peter; Papaioannou, Chris G.; Moniot, Jerome L.; Mueller, Richard H.; Cimarusti, Christopher M.


Book ID
120077315
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
219 KB
Volume
6
Category
Article
ISSN
1083-6160

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An efficient, highly regioselective synt
โœ T.Howard Black; Stephen L Maluleka ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 208 KB

When treated with magnesium bromide, Spiro B-lactones undergo an ionization/elimination reaction to afford cyclohexenyl acetic acid derivatives in high yield and isomeric purity. Cyclohexenyl acetic acid derivatives occupy a position of some importance in organic chemistry, both as synthetic precurs