Regional studies of 5HT metabolism in human cerebral cortex
β Scribed by Artemio Roxas Jr; Huang Yung-yu; Robert Goode; David Shuster; Andrew J. Dwork; Michael Stanley
- Book ID
- 118318578
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 185 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0006-3223
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Human cerebral cortical synaptosomes were used to determine the 5-hydroxytryptamine (5-HT) receptor subtype to which the inhibitory presynaptic 5-HT autoreceptor belongs. The synaptosomes preincubated with [3H~5-HT were superfused and tritium overflow was stimulated by high K +. The K +-evoked triti
The formation of synaptic contacts in human cerebral cortex was compared in two cortical regions: auditory cortex (Heschl's gyrus) and prefrontal cortex (middle frontal gyrus). Synapse formation in both cortical regions begins in the fetus, before conceptual age 27 weeks. Synaptic density increases