Regional pulmonary function in metastatic carcinoma to the lung studied with xenon-133

✍ Scribed by M. Khalil Ali,; Clifton D. Howe; John M. Miller

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 668 KB
• Volume: 27
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197102)27:2<460::aid-cncr2820270234>3.0.co;2-g

✦ Synopsis

Lung function was studied in 21 patients with nodular pulmonary metastases. Routine pulmonary function studies demonstrated that reduction in vital capacity and arterial PO,, related to the degree of tumor involvement, are characteristic features of metastatic lung disease. The reduced arterial PO, is largely explained by increased right to left shunt. Regional pulmonary function studied with xenon-133 and 8 scintillation detectors revealed frequent ventilatory defects in the vicinity of single metastases. In patients with multiple bilateral metastases, defects in pulmonary blood flow and ventilation were commonly observed in the vicinity of the tumor masses.

HERE ARE FEW REPORTS ON THE EFFECTS OF

T pulmonary metastases on lung func-tion16. l o and none have dealt with regional pulmonary function. This study describes regional pulmonary ventilation and perfusion in patients with single and multiple modular metastatic lesions. Abnormalities of overall pulmonary function and zonal pulmonary function defects were correlated with the extent of the metastatic lesions.