Regional norepinephrine response to amphetamine using dialysis: Comparison with caudate dopamine

✍ Scribed by Ronald Kuczenski; David S. Segal

• Book ID: 104600434
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 590 KB
• Volume: 11
• Category: Article
• ISSN: 0887-4476
• DOI: 10.1002/syn.890110210

✦ Synopsis

The response of extracellular norepinephrine to the acute administration of amphetamine was assessed, using dialysis, in prefrontal cortex and hippocampus in awake, behaving rats. Norepinephrine exhibited a pronounced and rapid dose-and time-dependent increase in response to 0.5 and 2.5 mgkg amphetamine, which corresponded closely to the time course of the behavioral profile. These results are consistent in with a possible role for norepinephrine in the behavioral response to amphetamine.