𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Regional mapping of the human gene for lysosomal α-glucosidase by in situ hybridization

✍ Scribed by D.J.J. Halley; A. Konings; P. Hupkes; H. Galjaard

Publisher
Springer
Year
1984
Tongue
English
Weight
478 KB
Volume
67
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

✦ Synopsis

The current approach to the chromosomal localization of genes coding for lysosomal enzymes has been the correlation of enzymatic and karyotypic analyses of human-rodent somatic cell hybrids. The feasibility of regional mapping depends on the availability of human cells with informative chromosomal rearrangements. In this communication we report the first localization of a gene coding for a lysosomal enzyme by in situ hybridization. The application of an acid alpha-glucosidase cDNA probe to normal human chromosomes allowed direct regional mapping of the alpha-glucosidase locus (GAA) to the region q23----q25 of chromosome 17.

📜 SIMILAR VOLUMES

Regional mapping of the gene for human l
Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11
✍ Carol Jones; Fa-Ten Kao 📂 Article 📅 1978 🏛 Springer 🌐 English ⚖ 649 KB

A clone panel containing various segments of human chromosome 11 has been selected and use for regional assignment of the gene for human lysosomal acid phosphatase (ACP2) to the short arm of chromosome 11, in the region 11p11 leads to 11p12. Further evidence has also been presented to update the reg

Mapping of the ribophorin II (RPN II) ge
Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12–q13.1 by in-situ hybridization
✍ Christiane Löffler; V. V. N. Gopal Rao; Ingo Hansmann 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 187 KB

Ribophorin I and II (RPN I and RPN II), two specific glycoproteins, span the rough regions of the endoplasmic reticulum (RER) and are thought to play an important role either in translocation or in the maintenance of RER. Studies with human-mouse somatic cell hybrids have localized the gene for RPN