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Regional localisations and linkage relationships of seven RFLPs and myotonic dystrophy on chromosome 19

โœ Scribed by D. J. Shaw; A. L. Meredith; M. Sarfarazi; H. G. Harley; S. M. Huson; J. D. Brook; L. Bufton; M. Litt; T. Mohandas; P. S. Harper

Publisher
Springer
Year
1986
Tongue
English
Weight
521 KB
Volume
74
Category
Article
ISSN
0340-6717

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โœฆ Synopsis

We have studied the genetic linkage relationships of seven DNA polymorphisms on chromosome 19, with each other and with the myotonic dystrophy locus. The DNA sequences were localised to various regions of the chromosome using translocations in somatic cell hybrids. These results provide the basis for a linkage map of most of chromosome 19, and suggest that the myotonic dystrophy locus is close to the centromere.

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โœ D. J. Shaw; A. L. Meredith; J. D. Brook; M. Sarfarazi; H. G. Harley; S. M. Huson ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer ๐ŸŒ English โš– 251 KB

Myotonic dystrophy is associated with disturbances in the insulin response, possibly due to an abnormality of the insulin receptor. Both the myotonic dystrophy (DM) and insulin receptor (INSR) genes are on chromosome 19. Using a cloned gene probe for INSR, we have studied its linkage relationships w