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Regional heterogeneity of rat brain phencyclidine (PCP) receptors revealed by photoaffinity labeling with [3H] azido phencyclidine

✍ Scribed by Rachel Haring; Yoel Kloog; Mordechai Sokolovsky

Book ID: 115758290
Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 492 KB
Volume: 131
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(85)90206-2

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The phencyclidine (PCP) derivative N-[l-(2-thienyl) cyclohexyl]-piperidine (3H-TCP) was used to label in vivo the N-methyl-D-aspartate (NMDA) receptor-associated ionic channel in the mouse brain. After the injection of a tracer dose of 3H-TCP, a spread labeling throughout the brain was observed, but