Regional chromosomal localisation of APOA2 to 1q21–1q23
✍ Scribed by H. R. Middleton-Price; J. A. Berghe; J. Scott; T. J. Knott; S. Malcolm
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 336 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
Using in situ hybridisation, we have mapped APOA2 to the 1q21-1q23 region of chromosome 1. DNA hybridisation to somatic cell hybrids made from cells carrying a balanced translocation between X and 1 confirms the localisation as proximal to 1q23. This was further confirmed by the presence of two polymorphic alleles in a cell line carrying a deletion of 1q25-1q32.
📜 SIMILAR VOLUMES
We report on a girl with a phenotype and developmental profile initially suggestive of Angelman syndrome. Subsequently she was shown to have an interstitial deletion of the long arm of chromosome 17; [del(17)-(q23.1q23.3)], the smallest unique cytogenetic deletion in this region documented to date.