Twenty-two patients with liver metastases received 45 courses of recombinant tumor necrosis factor (rTNF] by hepatic arterial infusion in doses ranging from 12.5 to 175 pg/m2/d for 5 days by continuous infusion. The induction of statistically significant, dose-related, severe, albeit transient, hypo
โฆ LIBER โฆ
Regional biologic therapy. Hepatic arterial infusion of recombinant human tumor necrosis factor in patients with liver metastases
โ Scribed by Giora M. Mavligit; Alexander A. Zukixvski; Chuslip Charnsangavej; C. Humberto Carrasco; Sidney Wallace; Jordan U. Gutterman
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 514 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0008-543X
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Local and systemic toxicities associated with hepatic arterial infusion of human recombinant tumor necrosis factor (rTNF) were studied in healthy adult mongrel dogs. The animals received saline containing human serum albumin with or without rTNF (0.02, 0.2, or 2.0 mg/m2). Arteriograms were made, and