Region-selective alterations of glucose oxidation and amino acid synthesis in the thiamine-deficient rat brain: a re-evaluation using 1H/13C nuclear magnetic resonance spectroscopy

Brain lactate synthesis in thiamine defi

Brain lactate synthesis in thiamine deficiency: A re-evaluation using 1H-13C nuclear magnetic resonance spectroscopy

✍ Darren Navarro; Claudia Zwingmann; Alan S. Hazell; Roger F. Butterworth 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 324 KB 👁 1 views

## Abstract Region‐selective accumulation of brain lactate occurs in TD; however, the mechanisms responsible have not been elucidated fully. ^1^H and ^13^C nuclear magnetic resonance (NMR) spectroscopy were therefore used to investigate de novo lactate synthesis from [1‐^13^C]glucose in vulnerable