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Regiocontrolled synthesis of highly-functionalized fused imidazoles: a novel synthesis of second generation LFA-1 inhibitors

✍ Scribed by Rogelio P. Frutos; Michael Johnson

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 143 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01535-1

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✦ Synopsis

A new and reliable route to a new class of LFA-1 inhibitors such as (2) has been developed. A key aspect of this route is the transformation of amino amide 5 into iodide 3 in four steps. Iodide 3 is a key advanced intermediate used in the synthesis of all second-generation 1H-imidazo[1,2-a]imidazol-2-one LFA-1 inhibitors.

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