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Regiocontrolled addition in the reaction of N-(α-methoxyphenacyl)anilines with methyl lithioisobutyrate

✍ Scribed by Benito Alcaide; Carmen López-Hardomingo; Rafael Pérez-Ossorio; Joaquin Plumet; Julian Rodriguez-López

Book ID
104219230
Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
210 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

Reaction of various para-substituted tj-(a-methoxyphenacyl)anilines with lithioisobutyrate in excess gives,in good yield, compounds 2-6 through -a regiocontrolled process. In a previous paper', we have reported the synthesis and reactions of some novel substituted B-hydroxy-y-imino esters which can be easily obtained by reaction of o-iminoketones with lithium ester enolates in a totally site-\ -selective addition to the carbonyl group. In the present communication we report a simple versatile reaction between various para-substituted 2 tj-(a-methoxyphenacyl)anilines,

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