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Regiocontrol of nitrile oxide cycloadditions to allyl alcohols. Synthesis of 4-substituted and 4,4-disubstituted 5-hydroxymethyl-2-isoxazolines

✍ Scribed by Shuji Kanemasa; Masaki Nishiuchi; Eiji Wada

Publisher: Elsevier Science
Year: 1992
Tongue: French
Weight: 290 KB
Volume: 33
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)91622-8

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✦ Synopsis

The well established high synthetic utility of 2?-isoxazolines is due to their synthetic equivalency of a wide variety of important functionalized building blocks such as P-hydroxy ketones+ fi-amino alcohols, cr,punsaturated ketones, and related functionalities.'

Nitrile oxide cyclctaddition offers the most useful access IO 2isoxnzoline skeletons in which one carbon-carbon bond forming process is involved. Cycloadc-!itions of niuile

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