Regiocontrol in the 1,3-dipolar cycloaddition reactions of mesoionic compounds with acetylenic dipolarophiles
โ Scribed by Brian P. Coppola; Mark C. Noe; Sam Shih-Kuang Hong
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 230 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
of either N-benzoylalanine or N-acetylphenylgllcine. The preparative application of this new pyrrole synthesis is simplified by the fact that alkyloxazolones, which are unstable and difficult lo purify [I], can be used in sifu. Thus, (5) is obtained by the reaction of phenylglycine or N-acetylphenyl
Regiospecific nucleophilic substitution reactions involving attack of the nitrogen atom of oximes on epoxides are used to generate nitrones which are then trapped in 1,3-dipolar cycloaddition reactions. These tandem processes are shown to be flexible and to have wide synthetic scope for the construc