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Regio- and Stereospecific Synthesis of Mono-β- d -Glucuronic Acid Derivatives of Combretastatin A-1

✍ Scribed by Tanpure, Rajendra P.; Strecker, Tracy E.; Chaplin, David J.; Siim, Bronwyn G.; Trawick, Mary Lynn; Pinney, Kevin G.


Book ID
120021234
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
307 KB
Volume
73
Category
Article
ISSN
0163-3864

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UDC 547.854.4'293'273.04 &(1-Uracilyl)-a-substituted propionitriles were obtained by cyanohydrin synthesis from 1-uracilylacetaldehydes. Their hydrolysis, bromination, and amination were studied. We have previously shown that, depending on the reaction conditions, either replacement of the bromine