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Regio- and stereoselective fluorinative ring-opening reaction of epoxyalcohols by (i-PrO)2TiF2-Et4NF-nHF. Synthesis of optically active 3-fluoro-1,2-diols

โœ Scribed by Shoji Hara; Takuro Hoshio; Mikio Kameoka; Masataka Sawaguchi; Tsuyoshi Fukuhara; Norihiko Yoneda


Book ID
108379316
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
331 KB
Volume
55
Category
Article
ISSN
0040-4020

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Ring-opening of epoxyalcohols by diethyl
โœ Fabio Benedetti; Federico Berti; Stefano Norbedo ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 211 KB

Diethylaluminium cyanide is a highly selective reagent for the ring opening of 2,3-epoxyalcohols under mild conditions; the reaction takes place at C-3, with inversion of configuration, to give 1-cyano-2,3-diols.