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Regio and stereocontrolled synthesis of aryl cis aminoalcohols from cis glycols

✍ Scribed by Mahesh K. Lakshman; Barbara Zajc


Book ID
103410165
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
234 KB
Volume
37
Category
Article
ISSN
0040-4039

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Addition of aldehyde dimethyl acetals (here acetaldehyde) to unisolated O-trimethylsilyl derivatives of 1-acetyl-3-arylmethylpiperazine-2,5-diones (here 2,5-dimethoxyphenyl), in the presence of TMSOTf as the catalyst, gave nearly quantitatively the corresponding N-methoxyalkyl derivatives which, und