Regio- and diastereoselective addition of allylic thioethers to aldehydes

✍ Scribed by Diego Gamba-Sanchez; Raphaël Oriez; Joëlle Prunet

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 424 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.12.009

✦ Synopsis

We have developed a regioselective allylation and a regio-and diastereoselective crotylation of aldehydes with pyridin-2-yl sulfides. In the process, we have also optimized the diastereoselectivity of the addition of crotyl phenyl sulfide to aldehydes.