Regenerative activity of muscle tissue and thymus status in young and old mdx mice with muscle injury and wound xenoplasty

Muscle weakness and atrophy are associat

Muscle weakness and atrophy are associated with decreased regenerative capacity and changes in mTOR signaling in skeletal muscles of venerable (18–24-month-old) dystrophic mdx mice

✍ E. Mouisel; A. Vignaud; C. Hourdé; G. Butler-Browne; A. Ferry 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 714 KB

## Abstract The muscles of __mdx__ mice progressively deteriorate with age. We wanted to know whether this is associated with a decrease in regenerative capacity and/or changes in the mammalian target of rapamycin complex (mTOR) signaling pathway. Muscles of __mdx__ mice aged 5 weeks, 5, 12, and 18