✦ LIBER ✦

Regeneration through long nerve grafts in the swine model

✍ Scribed by Arthur Atchabahian; Eric M. Genden; Susan E. Mackinnon; Vaishali B. Doolabh; Daniel A. Hunter

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 117 KB
Volume: 18
Category: Article
ISSN: 0738-1085
DOI: 10.1002/(sici)1098-2752(1998)18:6<379::aid-micr7>3.0.co;2-5

No coin nor oath required. For personal study only.

✦ Synopsis

We investigated regeneration across a long nerve defect in the swine model to study extensive neural loss and long nerve gap. Most experiments have been conducted in the rodent model that, while an appropriate immunological model, only allows short nerve gaps to be studied. Twelve outbred swine received either an 8-cm ulnar nerve autograft or an allograft without immunosuppression. At 6 and 10 months, histomorphometry of the autografts demonstrated excellent nerve regeneration, while very poor regeneration was noted across the allografts. This confirmed that 8 cm are an adequate challenge independent of the spontaneous regeneration potential of axons seen in rodents. The swine ulnar nerve graft model causes minimal morbidity and will now be used with immunological manipulation of inbred animals.

📜 SIMILAR VOLUMES

Tissue specificity in rat peripheral ner

Tissue specificity in rat peripheral nerve regeneration through combined skeletal muscle and vein conduit grafts

✍ Pierluigi Tos; Bruno Battiston; Stefano Geuna; Maria G. Giacobini-Robecchi; Mark 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 299 KB 👁 2 views

Diffusible factors from the distal stumps of transected peripheral nerves exert a neurotropic effect on regenerating nerves in vivo (specificity). This morphological study was designed to investigate the existence of tissue specificity in peripheral nerve fiber regeneration through a graft of vein f

Effects of long-term treatment with α-gl

Effects of long-term treatment with α-glucosidase inhibitor on the peripheral nerve function and structure in Goto-Kakizaki rats: a genetic model for Type 2 diabetes

✍ Ryuichi Wada; Motoi Koyama; Hiroki Mizukami; Hiroyuki Odaka; Hitoshi Ikeda; Soro 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB 👁 1 views

Background Continuous hyperglycemia is implicated in the pathogenesis of chronic diabetic complications. It is not well known, however, how and to what extent the development of neuropathy is inhibited by blood glucose control in subjects with Type 2 diabetes. We investigated therefore the effects o