Regeneration of the rat sciatic nerve after different conditioning lesions: Effects of the conditioning interval

✍ Scribed by Craig Arntz; Dr. Martin Kanje; Göran Lundborg

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 369 KB
• Volume: 10
• Category: Article
• ISSN: 0738-1085
• DOI: 10.1002/micr.1920100210

✦ Synopsis

Regeneration of the rat sciatic nerve was studied after a crush lesion (test lesion) on nerves previously subjected to a conditioning lesion. The test lesion was made approximately 30 mm proximal to the conditioning lesion. The period between the conditioning lesion and the test lesion was varied. R e generation was measured by the pinch test. The conditioning procedure increased the rate of axonal elongation and decreased the initial delay. Conditioning intervals between 14 hours and 4 days were sufficient to increase the regeneration distance significantly, but only until day 4. If the conditioning interval was prolonged to 7 or 14 days, the conditioning effect persisted until day 6. A condRioning effect also was produced by transection of the sciatic nerve and by local compression produced with a silicone tube. The results of this study demonstrate that the type of injury and the conditioning intervals are important determinants in producing the conditioning effect in the rat.