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Regeneration of Bovine Pancreatic Ribonuclease A: Detailed Kinetic Analysis of Two Independent Folding Pathways †

✍ Scribed by Rothwarf, David M.; Li, Yue-Jin; Scheraga, Harold A.


Book ID
126289847
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
87 KB
Volume
37
Category
Article
ISSN
0006-2960

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The Tyr92-Pro93 peptide group of bovine pancreatic ribonuclease A (RNase A) exists in the cis conformation in the native state. From unfolding/refolding kinetic studies of the disulfide-intact wild-type protein and of a variant in which Pro93 had been replaced by Ala, it had been suggested that the