✦ LIBER ✦

Regeneration and repair of peripheral nerves with different biomaterials: Review

✍ Scribed by Maria Siemionow; Mehmet Bozkurt; Fatih Zor

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 179 KB
Volume: 30
Category: Article
ISSN: 0738-1085
DOI: 10.1002/micr.20799

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Peripheral nerve injury may cause gaps between the nerve stumps. Axonal proliferation in nerve conduits is limited to 10–15 mm. Most of the supportive research has been done on rat or mouse models which are different from humans. Herein we review autografts and biomaterials which are commonly used for nerve gap repair and their respective outcomes. Nerve autografting has been the first choice for repairing peripheral nerve gaps. However, it has been demonstrated experimentally that tissue engineered tubes can also permit lead to effective nerve repair over gaps longer than 4 cm repair that was previously thought to be restorable by means of nerve graft only. All of the discoveries in the nerve armamentarium are making their way into the clinic, where they are, showing great potential for improving both the extent and rate of functional recovery compared with alternative nerve guides. © 2010 Wiley‐Liss, Inc. Microsurgery, 2010.

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