Reflux of duodenal or gastro-duodenal contents induces esophageal carcinoma in rats

✍ Scribed by Koichi Miwa; Hiroyuki Sahara; Masataka Segawa; Shinichi Kinami; Takahiro Sato; Itsuo Miyazaki; Takanori Hattori

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 748 KB
• Volume: 67
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19960717)67:2<269::aid-ijc19>3.0.co;2-6

✦ Synopsis

Esophageal adenocarcinoma arises from Barrett's esophagus, which is induced by gastro-esophageal reflux. This refluxate often contains duodenal contents, whose backflow triggers gastric carcinoma, suggesting the hypothesis that refluxed duodenal contents cause esophageal carcinoma. This study examines the role of duodenal and gastric reflux in the absence of exogenous carcinogens in esophageal carcinogenesis. Wistar male rats, I20 in all, each weighing approximately 250 g, were used. Three experimental procedures were performed to produce gastro-duodeno-esophageal reflux. duodeno-esophageal reflux and gastro-esophageal reflux, for comparison with 2 control procedures, Roux-en-Y reconstruction and a sham operation. The animals were fed a standard diet and were examined 50 weeks after surgery. While no carcinoma was found among the I6 gastro-esophageal-reflux, I I Roux-en-Y and 12 sham-operation animals, 10 of the I 2 animals with gastro-duodeno-esophageal reflux (83%) and I 0 of the I 3 with duodeno-esophageal reflux (77%) developed esophageal carcinoma. The difference between groups was significant