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Refined mapping of the human Ets-related gene Elk-1 to Xp11.2–p11.4, distal to the OATL1 region

✍ Scribed by Martin Janz; Ulrich Lehmann; Danielle Olde Weghuis; Bertie Leeuw; Ad Geurts Kessel; Simone Gilgenkrantz; Robert A. Hipskind; Alfred Nordheim

Book ID
104661208
Publisher
Springer
Year
1994
Tongue
English
Weight
298 KB
Volume
94
Category
Article
ISSN
0340-6717

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✦ Synopsis

The gene for human Elk-1, an Ets-related transcription factor, has previously been localized to a region that lies on the short arm of chromosome X and that is involved in specific chromosomal translocations associated with synovial sarcoma and renal adenocarcinomas. We have used fluorescence in situ hybridization and a panel of tumor-derived somatic cell hybrids to refine the localization of Elk-1, in particular with regard to the rearrangements in these tumors. Elk-1 has been assigned to Xp11.2-p11.4, distal to the OATL1 region.

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