Chromosome 17p is among the most frequently deleted regions in a variety of human malignancies including breast cancer. This study has further refined the localization of a putative tumour suppressor gene (TSG) at 17p13 distal to the TP53 gene in breast carcinomas. It was found that 73% (37 of 51) o
✦ LIBER ✦
Refined deletion mapping in sporadic breast cancer at chromosomal region 8p12-p21 and association with clinicopathological parameters
✍ Scribed by S. Seitz; S. Werner; J. Fischer; A. Nothnagel; P.M. Schlag; S. Scherneck
- Book ID
- 117656871
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 433 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0959-8049
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Several genes, most of them unknown, of the short arm of chromosome 8 are involved in malignant diseases. Numerous studies have implicated a portion of the 8p11-p21 region as the location of one or more tumor suppressor genes involved in a variety of human cancers, including breast cancer. We and ot