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On Confidence Bounds for the Ratio of Ne

On Confidence Bounds for the Ratio of Net Differences in the “Gold Standard” Design with Reference, Experimental, and Placebo Treatment

✍ Joachim Röhmel 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB 👁 1 views

The three-arm clinical study including a placebo has been recommended to be the preferred study design for the comparison of an experimental treatment relative to a reference treatment. In a confirmatory three-arm study multiplicity issues arise that are not present in two-arm studies. In the past a