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Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo

✍ Scribed by Gaiddon, C.


Book ID
111746185
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
469 KB
Volume
18
Category
Article
ISSN
0261-4189

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The conserved region 1 and the extreme N-terminus of adenoviral oncoprotein E1A are essential for transforming activity. They also play roles in the interaction of E1A with p300/CBP and pRb and are involved in both transactivation and repression of host gene expression. It was reported recently that