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Reengineering Protein Specificity By Repacking the Hydrophobic Core

✍ Scribed by Tripp, Katherine W.; Horner, Geoffrey A.; Marqusee, Susan

Book ID
119206218
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
86 KB
Volume
98
Category
Article
ISSN
0006-3495

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## Abstract The T4 lysozyme mutant Ser 117 β†’ Phe was isolated fortuitously and found to be more thermostable than wild‐type by 1.1–1.4 kcal/mol. In the wild‐type structure, the side chain of Ser 117 is in a sterically restricted region near the protein surface and forms a short hydrogen bond with A