๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Reductive N-alkylation of secondary amines with [2-11C]acetone

โœ Scribed by Margaretha van der Meij; Nicholas I. Carruthers; Jacobus D.M. Herscheid; Jill A. Jablonowski; Josee E. Leysen; Albert D. Windhorst

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
116 KB
Volume
46
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

The development of a labeling method for secondary amines with [2โ€^11^C]acetone is described since the R~2~Nโ€isopropyl moiety is present in many biologically active compounds. The influence of a variety of parameters (e.g. reagents, solvents, temperature, and time) on the reaction outcome is discussed. Under the optimal reaction conditions, [^11^C]1โ€isopropylโ€4โ€phenylpiperazine ([^11^C]iPPP) was synthesized from [2โ€^11^C]acetone and 1โ€phenylpiperazine in a decayโ€corrected radiochemical yield of 72%. The overall synthesis time, from EOB to HPLC analysis of [^11^C]iPPP, was 20 min. Specific activity was 142โ€“208 GBq/ฮผmol at the end of synthesis. Copyright ยฉ 2003 John Wiley & Sons, Ltd.

๐Ÿ“œ SIMILAR VOLUMES

Kinetic studies of the N-alkylation of s
Kinetic studies of the N-alkylation of secondary amines with 1,2-dichloroethane
โœ H. Yang; F. C. Thyrion ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 348 KB

The reactions of 1,2-dichloroethane with 2-(ethylamino)ethanol or diethylamine have been investigated in several solvents from 51 to 80ยฐC. A reaction mechanism has been proposed where 1,2-dichloroethane reacts with the secondary amines in both bimolecular substitution (SN 2) and elimination (E2) rea

Reductive N-Alkylation of Aromatic Amine
Reductive N-Alkylation of Aromatic Amines and Nitro Compounds with Nitriles Using Polymethylhydrosiloxane.
โœ Ch. Raji Reddy; K. Vijeender; P. Bibhuti Bhusan; P. Phani Madhavi; S. Chandrasek ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons โš– 24 KB ๐Ÿ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.