Reductive deprotection of allyl, benzyl and sulfonyl substituted alcohols, amines and amides using a naphthalene-catalysed lithiation

✍ Scribed by Emma Alonso; Diego J. Ramón; Miguel Yus

• Book ID: 104208078
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 940 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(97)00920-4

✦ Synopsis

The reaction of different protected alcohols, amines and amides with lithium and a catalytic amount of naphthalene (4 mol %) in THF at low temperature leads to their deprotection under very mild reaction conditions, the process being in many cases chemoselective.