Reductive coupling of aromatic oxims and azines to 1,2-diamines using Zn-MsOH or Zn-TiCl4

✍ Scribed by Naoki Kise; Nasuo Ueda

• Book ID: 104230252
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 64 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00178-2

✦ Synopsis

The reduction of aromatic aldoxims and azines with Zn in the presence of MsOH or TiCl 4 afforded N,N%-unsubstituted 1,2-diamines in one-step. The reductive coupling with Zn-MsOH gave meso 1,2-diamines selectively, whereas dl 1,2-diamines were formed selectively by the reduction with Zn-TiCl 4 .