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Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O6-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance

✍ Scribed by Raymond P. Baumann; Philip G. Penketh; Kimiko Ishiguro; Krishnamurthy Shyam; Yong L. Zhu; Alan C. Sartorelli


Book ID
113489087
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
301 KB
Volume
79
Category
Article
ISSN
0006-2952

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