Reductions with NADH models. 3. The high reactivity of Hantzsch amides
β Scribed by Gelbard, Georges; Lin, Jian; Roques, Nathalie
- Book ID
- 118054366
- Publisher
- American Chemical Society
- Year
- 1992
- Tongue
- English
- Weight
- 674 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Abslract : The regioselectivity of the reduction of the cyclic enamide 2a with an NADH model compound was established using a deuterated model. The geometry of the substrate seems to play a fundamental role since cyclic derivatives 2a and 2d were reduced and non cyclic derivatives 2b and 2c were not
The reaction kinetics of the reactions of Hantzsch esters (HEH) and Hantzsch 4-aryl-1,4-dihydropyridines (4aryl-HEH) with the tropylium cation as a formal hydride acceptor were investigated. The observed kinetic isotope effect (KIE, k H /k D ), using HEH and 4,4-d 2 -HEH as substrates, was 4.16, sug