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Reduction of the Wnt inhibitor Dkk1 increases bone density in mice

✍ Scribed by Bryan T. MacDonald; Parul Sharma; Somying Patntirapong; Sivan M. Oyserman; Raymond E. Samuel; Xi He; A. Goldstein; Peter V. Hauschka


Book ID
116975682
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
48 KB
Volume
295
Category
Article
ISSN
0012-1606

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The role of Dkk1 in bone mass regulation
✍ Joseph S. Butler; David W. Murray; Conor J. Hurson; Julie O'Brien; Peter P. Dora πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 168 KB

## Abstract The Wnt/β‐catenin pathway is a major signaling cascade in bone biology, playing a key role in regulating bone development and remodeling, with aberrations in signaling resulting in disturbances in bone mass. The objectives of our study were to correlate serum Dkk1 expression with bone m