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Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells

✍ Scribed by M. QADURA; M. OTHMAN; B. WATERS; R. CHEGENI; K. WALKER; A. LABELLE; M. OZELO; C. HOUGH; D. LILLICRAP


Book ID
109152724
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
337 KB
Volume
6
Category
Article
ISSN
1538-7933

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## Abstract ## Background The development of anti‐factor VIII (FVIII) antibodies (inhibitors) is a critical concern when considering gene therapy as a potential treatment modality for hemophilia A. We used a hemophilia A mouse model bred on different genetic backgrounds to explore genetically cont