Rats chronically treated with increasing daily doses of delta 9-tetrahydrocannabinol (delta 9-THC) for up to 5 or 10 days exhibit a withdrawal-like behavioural response when challenged with clomipramine, a potent inhibitor of serotonin (5-hydroxytryptamine) reuptake, at the time when the next inject
Reduction of the behavioral effects of Δ9-tetrahydrocannabinol by hyperbaric pressure
✍ Scribed by J. Michael Walsh; Linda S. Burch
- Book ID
- 113217355
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 474 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0091-3057
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In an attempt to identify the possible role of brain biogenic amines and adrenocorticotrophic hormone (ACTH) release in the behavioral and physiological effects of A 9-tetrahydrocannabinol (THC), the time course of drug action was studied. THC (20 mg/kg) was administered daily for 1, 4, 21, or 42 da