Reduction of testosterone, androstendione and their derivatives by Aphanocladium album

✍ Scribed by Jadwiga Dmochowska-Gladysz; Teresa Kolek; Prof. Dr. Antoni Siewiński

• Book ID: 102910550
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 531 KB
• Volume: 29
• Category: Article
• ISSN: 0233-111X
• DOI: 10.1002/jobm.3620290102

✦ Synopsis

A strain of Aphanocladium album reduces the C-3 carbonyl group in testosterone or androstendione to to 3%-ally1 alcohol. In some derivatives of these steroids the same carbonyl group is reduced to allyl alcohol with stereospecificity, depending on whether chlorine at C-4 or a 17a-methyl group is present. On the other hand, the presence of C-4 methyl group, a C-19 hydroxy group, a '2-17 acetyl one, or a double bond conjugated with the 4-en-3-ketone system totally inhibits the formation of allyl alcohols at C-3.

At the samC time, the C-17 carbonyl group in androstendione or in its derivatives is reduced to a respective 17/3-alcohol.

In the derivativw with arf additional 2-exomethylene group the double bond at this group is reduced.