Reduction of surface roughness of a laminin–apatite composite coating via inhibitory effect of magnesium ions on apatite crystal growth
✍ Scribed by Ayako Oyane; Yuusuke Ishikawa; Atsushi Yamazaki; Yu Sogo; Katsuko Furukawa; Takashi Ushida; Atsuo Ito
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 576 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1742-7061
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✦ Synopsis
An artificial material coated with a laminin-apatite composite layer on its surface would be useful as a percutaneous device with cell-adhesion properties and good biocompatibility. The present authors recently prepared such a composite by a liquid-phase coating process in which a surface-modified material was immersed in a laminin-containing calcium phosphate solution (LCP solution) supersaturated with respect to apatite. As a result of this coating process, however, the material increased in surface roughness, which may have an adverse effect on the prevention of bacterial infection. In the present study, a reduction of the surface roughness of the lamininapatite composite layer was attempted by adding MgSO 4 to the LCP solution as an inhibitor of apatite crystal growth. The surface roughness, Ra, of the resulting laminin-apatite composite layer decreased from approximately 0.43 to 0.31 lm upon increasing the MgSO 4 concentration in the LCP solution from 0 to 1.5 mM, while retaining its cell adhesion characteristics. The thus-obtained material, having a laminin-apatite composite coating with reduced surface roughness, has potential as a material for percutaneous devices with improved resistance to bacterial infection through the interface between the device and the skin.