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Reduction of reperfusion injury edema with corticotropin-releasing factor (CRF): A pilot study

✍ Scribed by Timothy M. Whitney; Michael L. Bentz; Peter C. Johnson

Book ID: 101266917
Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 40 KB
Volume: 18
Category: Article
ISSN: 0738-1085
DOI: 10.1002/(sici)1098-2752(1998)18:2<76::aid-micr3>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

Regulation of capillary permeability with ischemic reperfusion injury is a complex interaction between vascular endothelium and circulating blood factors. Corticotropin-releasing factor (CRF), a 41 -amino acid peptide CNS neurotransmitter known to modulate the pituitary-adrenal axis during stress response, has been shown to affect capillary leakage after thermal injury in peripheral tissue. When administered prior to ischemic reperfusion injury in a pedicled rat hindlimb model, CRF (80 mcg/kg) reduced limb weight gain to approximately 50% of saline control, suggesting a role for CRF in control of vascular permeability. The characteristics of CRF are reviewed.

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