Reduction of relative resting myocardial blood flow is related to myocardial delayed enhancement, T2-signal abnormalities, left-ventricular wall thickness and age in patients with hypertrophic cardiomyopathy
✍ Scribed by Katja Hueper; Antonia Zapf; Jan Skrok; Aurelio C Pinheiro; Thomas A Goldstein; Jie Zheng; Stefan L Zimmerman; Ihab R Kamel; M Roselle Abraham; Frank Wacker; David A Bluemke; Theodore Abraham; Jens Vogel-Claussen
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 236 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1097-6647
No coin nor oath required. For personal study only.
✦ Synopsis
By cardiac MRI we investigated the relationship of resting myocardial blood flow (MBF) in hypertrophic cardiomyopathy (HCM) patients to important parameters of disease. MBF was quantified on pixel-by-pixel basis in 804 segments in 70 patients. Relative MBF negatively correlated with left-ventricular (LV) wall thickness (p<0.001), extent of myocardial delayed enhancement (MDE; p<0.001), edema (T2 bright; p<0.001), T2 dark signal (p<0.001) and age (p=0.032), but not LV outflow gradient (p=0.901). Different perfusion patterns in segments with reduced and elevated resting perfusion were observed, which may represent different stages of HCM.