Reduction of piperidinoisoxazolidines: Competitive cyclisation to indolizidines or epoxides

✍ Scribed by Ramón Alibés; Félix Busqué; Pedro de March; Marta Figueredo; Josep Font

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 464 KB
• Volume: 54
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(98)00677-2

✦ Synopsis

In the reduction of polysubstituted piperidinoisoxazolidines, we have observed two competitive cyclisation pathways, leading to either indolizidines or epoxides. The yields of indolizidines can be optimised by an appropriate choice of the reducing agent and through a careful control of the workup conditions.