Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor β/bone morphogenetic protein inhibitors during experimental osteoarthritis

Resemblance of osteophytes in experiment

Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor β–induced osteophytes: Limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation

✍ E. N. Blaney Davidson; E. L. Vitters; H. M. van Beuningen; F. A. J. van de Loo; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 764 KB

## Abstract ## Objective Osteoarthritis (OA) is characterized by cartilage damage, synovial fibrosis, and osteophyte formation. Both transforming growth factor β (TGFβ) and bone morphogenetic protein 2 (BMP‐2) can induce the formation of osteophytes during OA, but their specific role in this proce