Reduction of Mitochondrial Reserve Capacity in Endothelial Cells by Nitric Oxide and Superoxide - Detection and Quantitation of Peroxynitrite Formed from Cogenerated Nitric Oxide and Superoxide
โ Scribed by Jacek Zielonka; Brian P Dranka; Monika Zielonka; Joy Joseph; Micael Hardy; Adam Sikora; Balaraman Kalyanaraman
- Book ID
- 113631544
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 395 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0891-5849
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๐ SIMILAR VOLUMES
Simple acidification o f aqueous alkaline peroxynitrite quantitatively generates singlet ('Ag) molecular oxygen, detected and quantitated spectroscopically (1 270 nm). This observation provides a chemical basis for physiological cytotoxicity o f ONOO-generated i n the diffusioncontrolled reaction o
Luminol chemiluminescence in phorbolester-activated cultured rat liver Kupffer cells was strongly inhibited by the selenoorganic compound ebselen (IC50 = 2 mumol/L). Ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]one) also diminished reduction of ferricytochrome c (IC50 = 10 mumol/L), indicating a supp