✦ LIBER ✦
Reduction of iminium ethers with sodium boro[3H] hydride. Preparation of tritium labelled clomiphene and nitromiphene (CI 628)
✍ Scribed by Peter C. Ruenitz; Jerome R. Bagley
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 248 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
3
3 The preparation of [ HI-clomiphene and [ HI-nitromiphene fro NaB H is described. The radiochemical yield and specific activlty of the former are 34% and 16 mCi/mmol and those of the latter were 42% and 20 mCi/mmol, respectively. The method described is of micromolar scale designed for maintaining cost economy in the purchase of expensive radiolabelled reagents while yielding final products of sufficient radioactivity for in vitro and in vivo metabolism studies.