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Reduction of GAD-67 MRNA in the striatum of patients with schizophrenia and bipolar disorder

✍ Scribed by C. Shannon-Weickert; J.E. Wyatt; B.K. Lipska; J.E. Kleinman; M.J. Webster


Book ID
119555667
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
128 KB
Volume
60
Category
Article
ISSN
0920-9964

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## Abstract γ‐Aminobutyric acid (GABA), the principal inhibitory neurotransmitter of CNS, has been consistently implicated in the pathophysiology of schizophrenia. GABA is synthesized from glutamate by the enzyme glutamic acid decarboxylase (GAD). Two isoforms of GAD have been identified and have b