Reduction of food consumption and body weight of normal and obese mice by chronic treatment with fluoxetine: A serotonin reuptake inhibitor
✍ Scribed by Terence T. Yen; David T. Wong; Kerry G. Bemis
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 454 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
✦ Synopsis
Fluoxetine, a serotonin reuptake inhibitor, reduced the food intake and body weight of both normal mice and viable yellow obese mice fed ad libitum. Fluoxetine was given at 10 mg/ kg, i.p., daily for 10 days or fed in the diet at a concentration of 0.04% for 21 days. In both experiments, mice did not develop tolerance to the compound. In the 21-day experiment, however, the decrease of food intake of normal mice was the same from week to week, and weight reduction was more in the first week than in the third week, suggeSting an adjustment of metabolism or feed efficiency that did not occur in the obese mice. Heat production of mice fed fluoxetine was not different from that of control mice. Fluoxetine treatment reduced the uptake of serotonin in homogenates of various brain regions and the number of 3H-5HT binding sites but did not alter the dissociation constants. This study demonstrates that fluoxetine is an orally effective antiobesity agent in both normal and obese mice and does not elicit tolerance in these mice for at least 3 weeks.